IPEC e-newsletter - Excipients Insight November/December 2013 - 20-12-13


Inside this issue


Bacterial cellulose: an alternative to MCC?

Researchers in Malaysia describe a novel excipient based on bacterial cellulose in the journal Carbohydrate Polymers, suggesting it could be a renewable, sustainable and biocompatible alternative to microcrystalline cellulose (MCC).

The report shows that BC prepared from nata de coco - a jelly-like foodstuff produced by the fermentation of coconut water - is chemically similar to MCC and is "satisfactorily pure". When spray-dried the excipient formed granular microparticles that were more spherical than those made using MCC, which significantly enhanced the physical properties and flowability of the powders.

BC also showed higher thermal stability, higher water retention capacity and swelling index compared to MCC, write the authors.

"The results suggest that spray drying of acid-treated and mechanically processed BC powder improves its physical properties, [and] provide new insights on the potential applications of spray-dried BC powders as promising pharmaceutical excipients," they conclude.




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